Drug interactions
Belladonna and opium + Metoclopramide
Severity: Moderate
Belladonna and opium and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The anticholinergic and opioid components slow gastrointestinal motility and counteract the prokinetic effect of metoclopramide. Opioid-related sedation may also be increased.
What this interaction means in plain words
Belladonna and opium and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism of cholinergic prokinetic action, with additive CNS depression.
What to do
Avoid combining when a prokinetic effect is needed. Monitor for sedation if both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Belladonna and opium with Metoclopramide?
MediHelp rates the interaction as moderate. Belladonna and opium and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The anticholinergic and opioid components slow gastrointestinal motility and counteract the prokinetic effect of metoclopramide. Opioid-related sedation may also be increased.
How serious is the interaction between Belladonna and opium and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when a prokinetic effect is needed. Monitor for sedation if both are used.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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