Drug interactions
Belladonna and opium + Prochlorperazine
Severity: Major
Belladonna and opium and Prochlorperazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination adds sedation and respiratory depression from the opium component to the anticholinergic effects of both belladonna and prochlorperazine. This increases the risk of drowsiness, constipation, urinary retention and confusion.
What this interaction means in plain words
Belladonna and opium and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression plus additive antimuscarinic effects.
What to do
Use the lowest effective doses and monitor sedation, respiratory rate and bowel and bladder function. Avoid in frail or elderly patients when possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Belladonna and opium with Prochlorperazine?
MediHelp rates the interaction as major. Belladonna and opium and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The combination adds sedation and respiratory depression from the opium component to the anticholinergic effects of both belladonna and prochlorperazine. This increases the risk of drowsiness, constipation, urinary retention and confusion.
How serious is the interaction between Belladonna and opium and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory rate and bowel and bladder function. Avoid in frail or elderly patients when possible.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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