Drug interactions
Buprenorphine long-acting + Propofol
Severity: Major
Buprenorphine long-acting and Propofol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-acting injectable buprenorphine gives sustained opioid levels that add to propofol's sedative and respiratory depressant effects. The prolonged exposure means the interaction persists for weeks.
What this interaction means in plain words
Buprenorphine long-acting and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid receptor activity and propofol's GABAergic action.
What to do
Use reduced, titrated propofol doses with continuous capnography and pulse oximetry. Plan for airway support and extended post-procedure observation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propofol
Frequently asked questions
Can I take Buprenorphine long-acting with Propofol?
MediHelp rates the interaction as major. Buprenorphine long-acting and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Long-acting injectable buprenorphine gives sustained opioid levels that add to propofol's sedative and respiratory depressant effects. The prolonged exposure means the interaction persists for weeks.
How serious is the interaction between Buprenorphine long-acting and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced, titrated propofol doses with continuous capnography and pulse oximetry. Plan for airway support and extended post-procedure observation.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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