Drug interactions
Belumosudil + Omeprazole
Severity: Moderate
Belumosudil and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid-reducing drugs such as omeprazole lower belumosudil exposure. This could reduce efficacy in chronic graft-versus-host disease.
What this interaction means in plain words
Belumosudil and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belumosudil belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces the solubility and absorption of belumosudil.
What to do
Increase belumosudil to 200 mg once daily to twice daily dosing as labeled when given with a proton pump inhibitor. Monitor GVHD response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Belumosudil
- Amobarbital + Belumosudil Moderate
- Apalutamide + Belumosudil Moderate
- Armodafinil + Belumosudil Moderate
- Belumosudil + Bosentan Moderate
- Belumosudil + Carbamazepine Moderate
- Belumosudil + Dexlansoprazole Moderate
Frequently asked questions
Can I take Belumosudil with Omeprazole?
MediHelp rates the interaction as moderate. Belumosudil and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Acid-reducing drugs such as omeprazole lower belumosudil exposure. This could reduce efficacy in chronic graft-versus-host disease.
How serious is the interaction between Belumosudil and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase belumosudil to 200 mg once daily to twice daily dosing as labeled when given with a proton pump inhibitor. Monitor GVHD response.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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