Drug interactions
Belzutifan + Chloroquine
Severity: Minor
Belzutifan and Chloroquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan can induce CYP3A4, which may lower chloroquine exposure. Chloroquine is only partly metabolised by CYP3A4, so the effect on antimalarial or antirheumatic efficacy is probably small and has not been well characterised.
What this interaction means in plain words
Belzutifan and Chloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Belzutifan belongs to Miscellaneous; Chloroquine belongs to Anti Parasitic.
Why it happens
Belzutifan induces CYP3A4 and may increase the metabolic clearance of chloroquine.
What to do
No routine dose change is needed. Monitor for reduced therapeutic response, particularly when chloroquine is used for malaria treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Chloroquine?
MediHelp rates the interaction as minor. Belzutifan and Chloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Belzutifan can induce CYP3A4, which may lower chloroquine exposure. Chloroquine is only partly metabolised by CYP3A4, so the effect on antimalarial or antirheumatic efficacy is probably small and has not been well characterised.
How serious is the interaction between Belzutifan and Chloroquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for reduced therapeutic response, particularly when chloroquine is used for malaria treatment.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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