Drug interactions
Belzutifan + Ergotamine
Severity: Moderate
Belzutifan and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan can induce CYP3A4 and may lower ergotamine concentrations, reducing efficacy for migraine. Ergotamine has a narrow margin, so changes in exposure matter.
What this interaction means in plain words
Belzutifan and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Ergotamine belongs to Central Nervous System.
Why it happens
Belzutifan induces CYP3A4, increasing ergotamine metabolism.
What to do
Monitor for loss of migraine control and consider an alternative therapy. Do not raise ergotamine doses beyond labeled limits because of ergotism risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Ergotamine?
MediHelp rates the interaction as moderate. Belzutifan and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan can induce CYP3A4 and may lower ergotamine concentrations, reducing efficacy for migraine. Ergotamine has a narrow margin, so changes in exposure matter.
How serious is the interaction between Belzutifan and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of migraine control and consider an alternative therapy. Do not raise ergotamine doses beyond labeled limits because of ergotism risk.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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