Drug interactions
Belzutifan + Esomeprazole
Severity: Minor
Belzutifan and Esomeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and may lower esomeprazole exposure. Esomeprazole is mainly metabolized by CYP2C19, so the effect is likely small.
What this interaction means in plain words
Belzutifan and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Belzutifan belongs to Miscellaneous; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Belzutifan induces CYP3A4, increasing the minor metabolic pathway of esomeprazole.
What to do
Monitor for reduced acid suppression and increase the esomeprazole dose if symptoms are not controlled.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Esomeprazole?
MediHelp rates the interaction as minor. Belzutifan and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Belzutifan induces CYP3A4 and may lower esomeprazole exposure. Esomeprazole is mainly metabolized by CYP2C19, so the effect is likely small.
How serious is the interaction between Belzutifan and Esomeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced acid suppression and increase the esomeprazole dose if symptoms are not controlled.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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