Drug interactions
Belzutifan + Everolimus
Severity: Moderate
Belzutifan and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and may lower everolimus concentrations, reducing efficacy or immunosuppressive effect. Belzutifan also causes anemia, which may overlap with everolimus hematologic effects.
What this interaction means in plain words
Belzutifan and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Everolimus belongs to Oncology.
Why it happens
Belzutifan induces CYP3A4, increasing the metabolism of everolimus.
What to do
Monitor everolimus response, and trough concentrations if used in transplant or other settings where levels guide dosing. Adjust the everolimus dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Everolimus?
MediHelp rates the interaction as moderate. Belzutifan and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan induces CYP3A4 and may lower everolimus concentrations, reducing efficacy or immunosuppressive effect. Belzutifan also causes anemia, which may overlap with everolimus hematologic effects.
How serious is the interaction between Belzutifan and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus response, and trough concentrations if used in transplant or other settings where levels guide dosing. Adjust the everolimus dose as needed.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
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