Drug interactions
Belzutifan + Gemfibrozil
Severity: Moderate
Belzutifan and Gemfibrozil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan is cleared by UGT2B17 and CYP2C19, and gemfibrozil may inhibit these pathways, increasing belzutifan exposure. Higher exposure raises the risk of anemia and hypoxia.
What this interaction means in plain words
Belzutifan and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Gemfibrozil belongs to Cardiovascular.
Why it happens
Gemfibrozil inhibits CYP2C19 and glucuronidation, reducing belzutifan metabolism.
What to do
Monitor hemoglobin and oxygen saturation, and reduce the belzutifan dose according to labeling if anemia or hypoxia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Gemfibrozil?
MediHelp rates the interaction as moderate. Belzutifan and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan is cleared by UGT2B17 and CYP2C19, and gemfibrozil may inhibit these pathways, increasing belzutifan exposure. Higher exposure raises the risk of anemia and hypoxia.
How serious is the interaction between Belzutifan and Gemfibrozil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and oxygen saturation, and reduce the belzutifan dose according to labeling if anemia or hypoxia develops.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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