Drug interactions
Belzutifan + Modafinil
Severity: Moderate
Belzutifan and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan is partly cleared by CYP2C19, which modafinil may weakly inhibit. Higher belzutifan exposure could worsen anemia and hypoxia.
What this interaction means in plain words
Belzutifan and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Modafinil belongs to Central Nervous System.
Why it happens
Modafinil inhibition of CYP2C19 may reduce belzutifan metabolism.
What to do
Monitor hemoglobin and oxygen saturation, and reduce the belzutifan dose if anemia or hypoxia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Modafinil?
MediHelp rates the interaction as moderate. Belzutifan and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan is partly cleared by CYP2C19, which modafinil may weakly inhibit. Higher belzutifan exposure could worsen anemia and hypoxia.
How serious is the interaction between Belzutifan and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and oxygen saturation, and reduce the belzutifan dose if anemia or hypoxia develops.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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