Drug interactions
Benazepril + Bortezomib
Severity: Moderate
Benazepril and Bortezomib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib can cause hypotension, including orthostatic hypotension, and an ACE inhibitor may add to this effect. Patients with dehydration or autonomic neuropathy are at higher risk.
What this interaction means in plain words
Benazepril and Bortezomib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Bortezomib belongs to Oncology.
Why it happens
Additive blood pressure lowering; bortezomib may also cause autonomic dysfunction and volume depletion.
What to do
Monitor blood pressure during bortezomib treatment and reduce or hold benazepril if symptomatic hypotension occurs; ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benazepril and Bortezomib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Benazepril with Bortezomib?
MediHelp rates the interaction as moderate. Benazepril and Bortezomib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bortezomib can cause hypotension, including orthostatic hypotension, and an ACE inhibitor may add to this effect. Patients with dehydration or autonomic neuropathy are at higher risk.
How serious is the interaction between Benazepril and Bortezomib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during bortezomib treatment and reduce or hold benazepril if symptomatic hypotension occurs; ensure adequate hydration.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
