Drug interactions
Benazepril + Dalteparin
Severity: Moderate
Benazepril and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Low molecular weight heparins can suppress aldosterone synthesis, and together with an ACE inhibitor this may produce hyperkalemia. The risk is higher with renal impairment, diabetes or prolonged heparin use.
What this interaction means in plain words
Benazepril and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Dalteparin belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of adrenal aldosterone secretion adds to ACE inhibitor-related reduction of aldosterone, impairing potassium excretion.
What to do
Check serum potassium and renal function, particularly in high-risk patients or when heparin is continued beyond several days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Benazepril with Dalteparin?
MediHelp rates the interaction as moderate. Benazepril and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Low molecular weight heparins can suppress aldosterone synthesis, and together with an ACE inhibitor this may produce hyperkalemia. The risk is higher with renal impairment, diabetes or prolonged heparin use.
How serious is the interaction between Benazepril and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function, particularly in high-risk patients or when heparin is continued beyond several days.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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