Drug interactions
Benazepril + Desflurane
Severity: Moderate
Benazepril and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desflurane causes dose-dependent vasodilation and hypotension. In patients taking benazepril, anesthesia-related hypotension can be more pronounced because the renin-angiotensin system is blocked.
What this interaction means in plain words
Benazepril and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Desflurane belongs to Central Nervous System.
Why it happens
Additive vasodilation and blunted compensatory angiotensin II response during volatile anesthesia.
What to do
Monitor blood pressure closely during induction and maintenance, and have fluids and vasopressors ready. Follow local guidance on whether to hold the ACE inhibitor before surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Desflurane
Frequently asked questions
Can I take Benazepril with Desflurane?
MediHelp rates the interaction as moderate. Benazepril and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desflurane causes dose-dependent vasodilation and hypotension. In patients taking benazepril, anesthesia-related hypotension can be more pronounced because the renin-angiotensin system is blocked.
How serious is the interaction between Benazepril and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during induction and maintenance, and have fluids and vasopressors ready. Follow local guidance on whether to hold the ACE inhibitor before surgery.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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