Drug interactions
Benazepril + Dexmedetomidine
Severity: Moderate
Benazepril and Dexmedetomidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine lowers blood pressure and heart rate through central sympatholysis, and may add to the hypotensive effect of benazepril, particularly during procedural sedation.
What this interaction means in plain words
Benazepril and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Dexmedetomidine belongs to Central Nervous System.
Why it happens
Additive hypotension from alpha-2 agonist-mediated sympathetic suppression and ACE inhibition.
What to do
Monitor blood pressure and heart rate continuously during dexmedetomidine infusion and treat hypotension with fluids or dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Benazepril with Dexmedetomidine?
MediHelp rates the interaction as moderate. Benazepril and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmedetomidine lowers blood pressure and heart rate through central sympatholysis, and may add to the hypotensive effect of benazepril, particularly during procedural sedation.
How serious is the interaction between Benazepril and Dexmedetomidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously during dexmedetomidine infusion and treat hypotension with fluids or dose reduction.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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