Drug interactions
Benazepril + Ethacrynic acid
Severity: Moderate
Benazepril and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics cause volume depletion, and adding an ACE inhibitor can lead to marked first-dose hypotension and acute decline in renal function. The risk is highest in patients who are sodium depleted, elderly, or have renal impairment.
What this interaction means in plain words
Benazepril and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Diuretic-induced volume and sodium depletion activates the renin-angiotensin system, so blocking it with an ACE inhibitor causes a pronounced fall in blood pressure and glomerular filtration.
What to do
Consider reducing or temporarily holding the diuretic before starting benazepril, and start with a low dose. Monitor blood pressure, creatinine and potassium in the first weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Benazepril with Ethacrynic acid?
MediHelp rates the interaction as moderate. Benazepril and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics cause volume depletion, and adding an ACE inhibitor can lead to marked first-dose hypotension and acute decline in renal function. The risk is highest in patients who are sodium depleted, elderly, or have renal impairment.
How serious is the interaction between Benazepril and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing or temporarily holding the diuretic before starting benazepril, and start with a low dose. Monitor blood pressure, creatinine and potassium in the first weeks.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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