Drug interactions
Benazepril + Ethinyl estradiol-drospirenone
Severity: Moderate
Benazepril and Ethinyl estradiol-drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium. ACE inhibitors also reduce aldosterone and retain potassium, so together they may cause hyperkalemia, especially with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Benazepril and Ethinyl estradiol-drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Additive potassium retention through drospirenone aldosterone antagonism and ACE inhibitor suppression of aldosterone.
What to do
Check serum potassium during the first treatment cycle and periodically thereafter. Avoid in patients with renal impairment or on other potassium-sparing agents, and consider another contraceptive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benazepril and Ethinyl estradiol-drospirenone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as moderate. Benazepril and Ethinyl estradiol-drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium. ACE inhibitors also reduce aldosterone and retain potassium, so together they may cause hyperkalemia, especially with renal impairment or other potassium-raising drugs.
How serious is the interaction between Benazepril and Ethinyl estradiol-drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first treatment cycle and periodically thereafter. Avoid in patients with renal impairment or on other potassium-sparing agents, and consider another contraceptive.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
