Drug interactions
Benazepril + Fluphenazine
Severity: Minor
Benazepril and Fluphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine has alpha-adrenergic blocking activity that can lower blood pressure, and this may add to the effect of benazepril. Orthostatic hypotension and dizziness may occur, particularly in older patients or at treatment start.
What this interaction means in plain words
Benazepril and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effect from alpha-blockade by the phenothiazine plus ACE inhibition.
What to do
Check standing blood pressure after starting or increasing either drug, and counsel the patient to rise slowly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Benazepril with Fluphenazine?
MediHelp rates the interaction as minor. Benazepril and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluphenazine has alpha-adrenergic blocking activity that can lower blood pressure, and this may add to the effect of benazepril. Orthostatic hypotension and dizziness may occur, particularly in older patients or at treatment start.
How serious is the interaction between Benazepril and Fluphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check standing blood pressure after starting or increasing either drug, and counsel the patient to rise slowly.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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