Drug interactions
Benazepril + Furosemide
Severity: Moderate
Benazepril and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an ACE inhibitor to furosemide, particularly in volume-depleted patients, can cause marked first-dose hypotension and acute decline in renal function. The combination is widely used in heart failure but needs care at initiation.
What this interaction means in plain words
Benazepril and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Furosemide belongs to Cardiovascular.
Why it happens
Additive hypotensive effect from volume depletion and loss of angiotensin II-mediated efferent arteriolar tone.
What to do
Consider temporarily lowering or holding the diuretic before starting benazepril, and check blood pressure, creatinine and potassium within one to two weeks. Counsel patients to report dizziness or reduced urine output.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Furosemide?
MediHelp rates the interaction as moderate. Benazepril and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding an ACE inhibitor to furosemide, particularly in volume-depleted patients, can cause marked first-dose hypotension and acute decline in renal function. The combination is widely used in heart failure but needs care at initiation.
How serious is the interaction between Benazepril and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider temporarily lowering or holding the diuretic before starting benazepril, and check blood pressure, creatinine and potassium within one to two weeks. Counsel patients to report dizziness or reduced urine output.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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