Drug interactions
Benazepril + Iloperidone
Severity: Moderate
Benazepril and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension. With benazepril, blood pressure lowering may be additive, increasing the risk of dizziness and falls.
What this interaction means in plain words
Benazepril and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Iloperidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic blockade and inhibition of the renin-angiotensin system.
What to do
Titrate iloperidone slowly and monitor orthostatic blood pressure. Reduce the benazepril dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Benazepril with Iloperidone?
MediHelp rates the interaction as moderate. Benazepril and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension. With benazepril, blood pressure lowering may be additive, increasing the risk of dizziness and falls.
How serious is the interaction between Benazepril and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate iloperidone slowly and monitor orthostatic blood pressure. Reduce the benazepril dose if symptomatic hypotension occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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