Drug interactions
Benazepril + Nitroglycerin
Severity: Moderate
Benazepril and Nitroglycerin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure through different vasodilatory and renin-angiotensin pathways, so combined use can produce additive hypotension. The effect is most pronounced with intravenous nitroglycerin or in volume-depleted patients, and may cause dizziness or syncope.
What this interaction means in plain words
Benazepril and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Nitroglycerin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilation and blood pressure lowering from ACE inhibition plus nitrate-mediated venodilation.
What to do
Monitor blood pressure and heart rate closely when starting or titrating IV nitroglycerin in patients taking benazepril. Reduce the nitrate infusion rate if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Nitroglycerin
- Avanafil + Nitroglycerin Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Nitroglycerin + Sildenafil Contraindicated
- Nitroglycerin + Tadalafil Contraindicated
- Nitroglycerin + Vardenafil Contraindicated
- Dihydroergotamine intranasal + Nitroglycerin Major
Frequently asked questions
Can I take Benazepril with Nitroglycerin?
MediHelp rates the interaction as moderate. Benazepril and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure through different vasodilatory and renin-angiotensin pathways, so combined use can produce additive hypotension. The effect is most pronounced with intravenous nitroglycerin or in volume-depleted patients, and may cause dizziness or syncope.
How serious is the interaction between Benazepril and Nitroglycerin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely when starting or titrating IV nitroglycerin in patients taking benazepril. Reduce the nitrate infusion rate if symptomatic hypotension develops.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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