Drug interactions
Benazepril + Perphenazine
Severity: Minor
Benazepril and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has alpha-blocking properties that can cause orthostatic hypotension, which may add to the antihypertensive effect of benazepril. The effect is usually mild but can cause dizziness and falls.
What this interaction means in plain words
Benazepril and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
Additive hypotension from phenothiazine alpha-adrenergic blockade and ACE inhibition.
What to do
Monitor blood pressure, including standing readings, after starting or changing either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Benazepril with Perphenazine?
MediHelp rates the interaction as minor. Benazepril and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine has alpha-blocking properties that can cause orthostatic hypotension, which may add to the antihypertensive effect of benazepril. The effect is usually mild but can cause dizziness and falls.
How serious is the interaction between Benazepril and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, after starting or changing either drug.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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