Drug interactions
Benazepril + Phentermine
Severity: Moderate
Benazepril and Phentermine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine has sympathomimetic activity and can raise blood pressure and heart rate. This may blunt the antihypertensive effect of benazepril.
What this interaction means in plain words
Benazepril and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Phentermine belongs to Central Nervous System.
Why it happens
Sympathomimetic-induced catecholamine release increases blood pressure, opposing ACE inhibitor effects (pharmacodynamic antagonism).
What to do
Monitor blood pressure after starting phentermine and adjust antihypertensive therapy as needed. Discontinue phentermine if blood pressure becomes uncontrolled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Benazepril with Phentermine?
MediHelp rates the interaction as moderate. Benazepril and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentermine has sympathomimetic activity and can raise blood pressure and heart rate. This may blunt the antihypertensive effect of benazepril.
How serious is the interaction between Benazepril and Phentermine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting phentermine and adjust antihypertensive therapy as needed. Discontinue phentermine if blood pressure becomes uncontrolled.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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