Drug interactions
Benazepril + Sirolimus
Severity: Moderate
Benazepril and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus combined with ACE inhibitors is associated with an increased risk of angioedema. Reactions can involve the face, lips, tongue, or airway and may be serious.
What this interaction means in plain words
Benazepril and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Sirolimus belongs to Miscellaneous.
Why it happens
Probably additive impairment of bradykinin metabolism, as mTOR inhibition may reduce DPP-4 activity alongside ACE inhibition.
What to do
Counsel patients to report any facial or throat swelling promptly. Stop the ACE inhibitor and consider an alternative antihypertensive if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Benazepril with Sirolimus?
MediHelp rates the interaction as moderate. Benazepril and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus combined with ACE inhibitors is associated with an increased risk of angioedema. Reactions can involve the face, lips, tongue, or airway and may be serious.
How serious is the interaction between Benazepril and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report any facial or throat swelling promptly. Stop the ACE inhibitor and consider an alternative antihypertensive if angioedema occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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