Drug interactions
Benazepril + Torsemide
Severity: Moderate
Benazepril and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an ACE inhibitor to a loop diuretic can cause marked hypotension and acute renal function decline, particularly at initiation or in volume-depleted patients or those with renal artery stenosis.
What this interaction means in plain words
Benazepril and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Why it happens
Diuretic volume depletion plus ACE inhibition lowers efferent arteriolar tone, causing additive hypotension and reduced glomerular filtration.
What to do
Consider reducing or temporarily holding torsemide before starting benazepril, and use a low starting dose. Monitor blood pressure, creatinine and potassium within one to two weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benazepril and Torsemide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Torsemide
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Torsemide?
MediHelp rates the interaction as moderate. Benazepril and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding an ACE inhibitor to a loop diuretic can cause marked hypotension and acute renal function decline, particularly at initiation or in volume-depleted patients or those with renal artery stenosis.
How serious is the interaction between Benazepril and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing or temporarily holding torsemide before starting benazepril, and use a low starting dose. Monitor blood pressure, creatinine and potassium within one to two weeks.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
