Drug interactions
Bendamustine + Tepotinib
Severity: Minor
Bendamustine and Tepotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may increase exposure to P-gp substrates. Bendamustine is not a clearly important P-gp substrate and is cleared mainly by hydrolysis, so a meaningful interaction is unlikely.
What this interaction means in plain words
Bendamustine and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bendamustine belongs to Oncology; Tepotinib belongs to Oncology.
Why it happens
Possible P-gp inhibition by tepotinib; clinical relevance for bendamustine is unestablished.
What to do
No specific action is needed beyond routine monitoring of blood counts and bendamustine toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bendamustine
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Bendamustine with Tepotinib?
MediHelp rates the interaction as minor. Bendamustine and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tepotinib inhibits P-glycoprotein and may increase exposure to P-gp substrates. Bendamustine is not a clearly important P-gp substrate and is cleared mainly by hydrolysis, so a meaningful interaction is unlikely.
How serious is the interaction between Bendamustine and Tepotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of blood counts and bendamustine toxicity.
What other medicines interact with Bendamustine?
MediHelp also lists interactions of Bendamustine with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Chlorambucil. The full list is on the Bendamustine page.
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