Drug interactions
Digoxin + Tepotinib
Severity: Major
Digoxin and Tepotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and increased digoxin exposure has been observed with coadministration. Because digoxin has a narrow therapeutic index, this can precipitate toxicity including arrhythmias.
What this interaction means in plain words
Digoxin and Tepotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Digoxin belongs to Cardiovascular; Tepotinib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by tepotinib increases digoxin absorption and decreases its efflux.
What to do
Avoid if possible; otherwise reduce the digoxin dose as appropriate and monitor digoxin levels, ECG and symptoms of toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Digoxin and Tepotinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
- Brentuximab + Tepotinib Moderate
Frequently asked questions
Can I take Digoxin with Tepotinib?
MediHelp rates the interaction as major. Digoxin and Tepotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tepotinib inhibits P-glycoprotein and increased digoxin exposure has been observed with coadministration. Because digoxin has a narrow therapeutic index, this can precipitate toxicity including arrhythmias.
How serious is the interaction between Digoxin and Tepotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the digoxin dose as appropriate and monitor digoxin levels, ECG and symptoms of toxicity.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
