Drug interactions
Apixaban + Tepotinib
Severity: Moderate
Apixaban and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-gp and may increase exposure to apixaban. The clinical impact is uncertain, but higher levels could raise bleeding risk.
What this interaction means in plain words
Apixaban and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Tepotinib belongs to Oncology.
Why it happens
Inhibition of intestinal P-gp efflux of apixaban.
What to do
Monitor for bleeding and check hemoglobin periodically. Consider an alternative anticoagulant in patients with renal impairment or other bleeding risks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
- Brentuximab + Tepotinib Moderate
Frequently asked questions
Can I take Apixaban with Tepotinib?
MediHelp rates the interaction as moderate. Apixaban and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-gp and may increase exposure to apixaban. The clinical impact is uncertain, but higher levels could raise bleeding risk.
How serious is the interaction between Apixaban and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check hemoglobin periodically. Consider an alternative anticoagulant in patients with renal impairment or other bleeding risks.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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