Drug interactions
Colchicine + Tepotinib
Severity: Major
Colchicine and Tepotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and can increase concentrations of P-gp substrates such as colchicine. This raises the risk of colchicine toxicity including diarrhea, cytopenias and myopathy.
What this interaction means in plain words
Colchicine and Tepotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits P-glycoprotein efflux of colchicine.
What to do
Avoid the combination where possible, or reduce the colchicine dose and monitor for toxicity. Avoid it in patients with renal or hepatic impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Tepotinib
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
- Brentuximab + Tepotinib Moderate
Frequently asked questions
Can I take Colchicine with Tepotinib?
MediHelp rates the interaction as major. Colchicine and Tepotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tepotinib inhibits P-glycoprotein and can increase concentrations of P-gp substrates such as colchicine. This raises the risk of colchicine toxicity including diarrhea, cytopenias and myopathy.
How serious is the interaction between Colchicine and Tepotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or reduce the colchicine dose and monitor for toxicity. Avoid it in patients with renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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