Drug interactions
Atorvastatin + Tepotinib
Severity: Moderate
Atorvastatin and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may increase atorvastatin exposure. This could raise the risk of statin-related muscle toxicity.
What this interaction means in plain words
Atorvastatin and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits intestinal P-glycoprotein efflux, increasing absorption of atorvastatin.
What to do
Monitor for myalgia and consider checking CK if muscle symptoms occur. Use the lowest effective atorvastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Brentuximab + Tepotinib Moderate
Frequently asked questions
Can I take Atorvastatin with Tepotinib?
MediHelp rates the interaction as moderate. Atorvastatin and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein and may increase atorvastatin exposure. This could raise the risk of statin-related muscle toxicity.
How serious is the interaction between Atorvastatin and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia and consider checking CK if muscle symptoms occur. Use the lowest effective atorvastatin dose.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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