Drug interactions
Tepotinib + Vincristine
Severity: Major
Tepotinib and Vincristine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein, which may raise vincristine exposure. Higher levels could worsen neurotoxicity and gastrointestinal toxicity.
What this interaction means in plain words
Tepotinib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tepotinib belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Tepotinib inhibits P-glycoprotein efflux, increasing vincristine absorption and reducing elimination.
What to do
Avoid concurrent use if possible. If unavoidable, monitor for neuropathy and constipation and reduce the vincristine dose when toxicity occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
- Brentuximab + Tepotinib Moderate
Frequently asked questions
Can I take Tepotinib with Vincristine?
MediHelp rates the interaction as major. Tepotinib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tepotinib inhibits P-glycoprotein, which may raise vincristine exposure. Higher levels could worsen neurotoxicity and gastrointestinal toxicity.
How serious is the interaction between Tepotinib and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible. If unavoidable, monitor for neuropathy and constipation and reduce the vincristine dose when toxicity occurs.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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