Drug interactions
Benperidol + Lisdexamfetamine
Severity: Moderate
Benperidol and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent dopamine antagonist and can blunt amphetamine effects, while stimulants may worsen psychotic symptoms. Both can influence cardiovascular function and cardiac conduction.
What this interaction means in plain words
Benperidol and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between amphetamine-induced dopamine release and D2 receptor blockade.
What to do
Monitor psychiatric symptoms and therapeutic response to both drugs. Consider ECG monitoring in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Benperidol with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Benperidol and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent dopamine antagonist and can blunt amphetamine effects, while stimulants may worsen psychotic symptoms. Both can influence cardiovascular function and cardiac conduction.
How serious is the interaction between Benperidol and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptoms and therapeutic response to both drugs. Consider ECG monitoring in patients with QT risk factors.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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