Drug interactions
Benperidol + Prochlorperazine
Severity: Major
Benperidol and Prochlorperazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dopamine antagonists, so combining them increases the risk of extrapyramidal symptoms, neuroleptic malignant syndrome and sedation. Benperidol is also associated with QT prolongation, which adds to prochlorperazine's risk.
What this interaction means in plain words
Benperidol and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive D2 receptor blockade and CNS depression.
What to do
Avoid combining two antipsychotics unless clearly justified. If used, monitor for movement disorders, fever and rigidity, and obtain an ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Benperidol with Prochlorperazine?
MediHelp rates the interaction as major. Benperidol and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are dopamine antagonists, so combining them increases the risk of extrapyramidal symptoms, neuroleptic malignant syndrome and sedation. Benperidol is also associated with QT prolongation, which adds to prochlorperazine's risk.
How serious is the interaction between Benperidol and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two antipsychotics unless clearly justified. If used, monitor for movement disorders, fever and rigidity, and obtain an ECG.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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