Drug interactions
Benperidol + Propofol
Severity: Moderate
Benperidol and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent butyrophenone antipsychotic that may add to propofol-induced sedation and hypotension. It can also prolong the QT interval, which is relevant during anesthesia.
What this interaction means in plain words
Benperidol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and alpha-blockade, with possible QT prolongation from benperidol.
What to do
Titrate propofol to effect at a reduced dose and monitor blood pressure and ECG. Correct electrolyte abnormalities beforehand.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Benperidol with Propofol?
MediHelp rates the interaction as moderate. Benperidol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent butyrophenone antipsychotic that may add to propofol-induced sedation and hypotension. It can also prolong the QT interval, which is relevant during anesthesia.
How serious is the interaction between Benperidol and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect at a reduced dose and monitor blood pressure and ECG. Correct electrolyte abnormalities beforehand.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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