Drug interactions
Benzhydrocodone / acetaminophen + Lisdexamfetamine
Severity: Moderate
Benzhydrocodone / acetaminophen and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase serotonergic activity and opioids have been rarely associated with serotonin syndrome. Amphetamine may also mask opioid sedation without reversing respiratory depression.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity and opposing CNS effects; hydrocodone exposure is not significantly altered.
What to do
Monitor for serotonin syndrome and for respiratory depression, particularly at initiation and dose increases. Stop the serotonergic drugs if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase serotonergic activity and opioids have been rarely associated with serotonin syndrome. Amphetamine may also mask opioid sedation without reversing respiratory depression.
How serious is the interaction between Benzhydrocodone / acetaminophen and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome and for respiratory depression, particularly at initiation and dose increases. Stop the serotonergic drugs if toxicity develops.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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