Drug interactions
Benzhydrocodone / acetaminophen + Metoclopramide
Severity: Moderate
Benzhydrocodone / acetaminophen and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gastric emptying and oppose the prokinetic action of metoclopramide, and both can cause sedation. Metoclopramide may also increase the rate of absorption of acetaminophen.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opioid-induced reduction in motility antagonizes metoclopramide, with additive CNS depression.
What to do
Monitor for sedation and reduced antiemetic or prokinetic effect. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Metoclopramide?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gastric emptying and oppose the prokinetic action of metoclopramide, and both can cause sedation. Metoclopramide may also increase the rate of absorption of acetaminophen.
How serious is the interaction between Benzhydrocodone / acetaminophen and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and reduced antiemetic or prokinetic effect. Use the lowest effective doses.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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