Drug interactions
Benzhydrocodone / acetaminophen + Prochlorperazine
Severity: Major
Benzhydrocodone / acetaminophen and Prochlorperazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a phenothiazine can produce profound sedation, respiratory depression, hypotension, coma and death. Opioid labeling warns about concurrent CNS depressants.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression and additive hypotension.
What to do
Reserve the combination for patients without adequate alternatives, using the lowest doses and shortest duration. Monitor sedation, respiratory rate and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Prochlorperazine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a phenothiazine can produce profound sedation, respiratory depression, hypotension, coma and death. Opioid labeling warns about concurrent CNS depressants.
How serious is the interaction between Benzhydrocodone / acetaminophen and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients without adequate alternatives, using the lowest doses and shortest duration. Monitor sedation, respiratory rate and blood pressure closely.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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