Drug interactions
Benzphetamine + Chlorpromazine
Severity: Moderate
Benzphetamine and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic anorectic, and chlorpromazine is a sedating dopamine antagonist, so their CNS effects oppose each other. Antipsychotics can reduce the anorectic effect of stimulants, and stimulants can worsen psychosis. Both can also affect heart rate and rhythm.
What this interaction means in plain words
Benzphetamine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing dopaminergic and adrenergic CNS effects, with possible additive cardiovascular effects.
What to do
Monitor psychiatric status, blood pressure, and heart rate. Avoid benzphetamine in patients with psychosis or significant cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Benzphetamine with Chlorpromazine?
MediHelp rates the interaction as moderate. Benzphetamine and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzphetamine is a sympathomimetic anorectic, and chlorpromazine is a sedating dopamine antagonist, so their CNS effects oppose each other. Antipsychotics can reduce the anorectic effect of stimulants, and stimulants can worsen psychosis. Both can also affect heart rate and rhythm.
How serious is the interaction between Benzphetamine and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric status, blood pressure, and heart rate. Avoid benzphetamine in patients with psychosis or significant cardiovascular disease.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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