Drug interactions
Benzphetamine + Prochlorperazine
Severity: Moderate
Benzphetamine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic stimulant and prochlorperazine is a sedating antipsychotic, so their central effects oppose each other. Phenothiazines may also blunt the anorectic effect of stimulants, and the combination can add cardiac stress.
What this interaction means in plain words
Benzphetamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing central dopaminergic and adrenergic effects; mechanism not fully established.
What to do
Monitor blood pressure, heart rate and mental status. Consider an alternative if there is a loss of efficacy or cardiovascular symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Benzphetamine with Prochlorperazine?
MediHelp rates the interaction as moderate. Benzphetamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzphetamine is a sympathomimetic stimulant and prochlorperazine is a sedating antipsychotic, so their central effects oppose each other. Phenothiazines may also blunt the anorectic effect of stimulants, and the combination can add cardiac stress.
How serious is the interaction between Benzphetamine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and mental status. Consider an alternative if there is a loss of efficacy or cardiovascular symptoms.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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