Drug interactions
Benztropine + Prochlorperazine
Severity: Moderate
Benztropine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine has anticholinergic activity that adds to that of benztropine, increasing dry mouth, constipation, urinary retention, confusion and tachycardia. Benztropine is often used deliberately to counter prochlorperazine-related extrapyramidal symptoms, but the anticholinergic burden should be monitored.
What this interaction means in plain words
Benztropine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benztropine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor blockade.
What to do
Use benztropine only when extrapyramidal symptoms occur and monitor for anticholinergic toxicity, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Benztropine
- Benztropine + Memantine-donepezil Major
- Abobotulinumtoxina + Benztropine Moderate
- Amantadine + Benztropine Moderate
- Amitriptyline + Benztropine Moderate
- Amoxapine + Benztropine Moderate
- Atropine iv / + Benztropine Moderate
Frequently asked questions
Can I take Benztropine with Prochlorperazine?
MediHelp rates the interaction as moderate. Benztropine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prochlorperazine has anticholinergic activity that adds to that of benztropine, increasing dry mouth, constipation, urinary retention, confusion and tachycardia. Benztropine is often used deliberately to counter prochlorperazine-related extrapyramidal symptoms, but the anticholinergic burden should be monitored.
How serious is the interaction between Benztropine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use benztropine only when extrapyramidal symptoms occur and monitor for anticholinergic toxicity, especially in older patients.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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