Drug interactions
Berotralstat + Cetirizine
Severity: Minor
Berotralstat and Cetirizine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and may raise cetirizine exposure, which is partly transported by this efflux pump. Higher cetirizine levels could increase drowsiness and other antihistamine adverse effects, although cetirizine has a wide margin of safety.
What this interaction means in plain words
Berotralstat and Cetirizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Berotralstat belongs to Miscellaneous; Cetirizine belongs to Respiratory.
Why it happens
Inhibition of P-glycoprotein efflux, reducing cetirizine elimination and increasing absorption.
What to do
Monitor for increased sedation and reduce the cetirizine dose if adverse effects occur. No routine adjustment is usually necessary.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Cetirizine?
MediHelp rates the interaction as minor. Berotralstat and Cetirizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Berotralstat inhibits P-glycoprotein and may raise cetirizine exposure, which is partly transported by this efflux pump. Higher cetirizine levels could increase drowsiness and other antihistamine adverse effects, although cetirizine has a wide margin of safety.
How serious is the interaction between Berotralstat and Cetirizine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and reduce the cetirizine dose if adverse effects occur. No routine adjustment is usually necessary.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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