Drug interactions
Berotralstat + Digoxin
Severity: Moderate
Berotralstat and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and can increase digoxin plasma concentrations. Higher exposure raises the risk of digoxin toxicity given its narrow therapeutic index.
What this interaction means in plain words
Berotralstat and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Digoxin belongs to Cardiovascular.
Why it happens
Inhibition of intestinal and renal P-glycoprotein reduces digoxin efflux and clearance.
What to do
Monitor serum digoxin concentrations and clinical signs of toxicity, and reduce digoxin dose as needed when starting berotralstat.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Digoxin?
MediHelp rates the interaction as moderate. Berotralstat and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein and can increase digoxin plasma concentrations. Higher exposure raises the risk of digoxin toxicity given its narrow therapeutic index.
How serious is the interaction between Berotralstat and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and clinical signs of toxicity, and reduce digoxin dose as needed when starting berotralstat.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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