Drug interactions
Berotralstat + Eletriptan
Severity: Moderate
Berotralstat and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein, and eletriptan is a P-gp substrate, so eletriptan levels may rise modestly. Berotralstat also inhibits CYP3A4 weakly to moderately, which may add to the increase.
What this interaction means in plain words
Berotralstat and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Eletriptan belongs to Central Nervous System.
Why it happens
Inhibition of P-gp efflux, and possibly CYP3A4, reducing eletriptan clearance.
What to do
Use the lowest effective eletriptan dose and monitor for increased triptan effects such as chest tightness, blood pressure rise, dizziness and nausea. Consider another triptan if effects are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Eletriptan?
MediHelp rates the interaction as moderate. Berotralstat and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein, and eletriptan is a P-gp substrate, so eletriptan levels may rise modestly. Berotralstat also inhibits CYP3A4 weakly to moderately, which may add to the increase.
How serious is the interaction between Berotralstat and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective eletriptan dose and monitor for increased triptan effects such as chest tightness, blood pressure rise, dizziness and nausea. Consider another triptan if effects are troublesome.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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