Drug interactions
Berotralstat + Risperidone
Severity: Moderate
Berotralstat and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein, and risperidone and its active metabolite 9-hydroxyrisperidone are P-gp substrates. Co-administration may raise risperidone exposure and increase dose-related adverse effects such as sedation, orthostatic hypotension and extrapyramidal symptoms.
What this interaction means in plain words
Berotralstat and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Risperidone belongs to Central Nervous System.
Why it happens
Berotralstat inhibits P-glycoprotein efflux, reducing risperidone clearance and increasing its absorption.
What to do
Monitor for increased antipsychotic effects and adverse reactions when starting berotralstat. Reduce the risperidone dose if sedation, hypotension or extrapyramidal symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Risperidone?
MediHelp rates the interaction as moderate. Berotralstat and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein, and risperidone and its active metabolite 9-hydroxyrisperidone are P-gp substrates. Co-administration may raise risperidone exposure and increase dose-related adverse effects such as sedation, orthostatic hypotension and extrapyramidal symptoms.
How serious is the interaction between Berotralstat and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased antipsychotic effects and adverse reactions when starting berotralstat. Reduce the risperidone dose if sedation, hypotension or extrapyramidal symptoms emerge.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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