Drug interactions
Betaxolol + Propofol
Severity: Moderate
Betaxolol and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol causes vasodilation and myocardial depression, and a beta-blocker can limit compensatory tachycardia and cardiac output. This may lead to deeper hypotension and bradycardia during anesthesia or sedation.
What this interaction means in plain words
Betaxolol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Propofol belongs to Central Nervous System.
Why it happens
Additive cardiovascular depression from propofol vasodilation and beta-blockade blunting compensatory responses.
What to do
Titrate propofol carefully with continuous hemodynamic monitoring, and have vasopressors and anticholinergics available. Continue chronic beta-blockers perioperatively unless otherwise indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Propofol
Frequently asked questions
Can I take Betaxolol with Propofol?
MediHelp rates the interaction as moderate. Betaxolol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol causes vasodilation and myocardial depression, and a beta-blocker can limit compensatory tachycardia and cardiac output. This may lead to deeper hypotension and bradycardia during anesthesia or sedation.
How serious is the interaction between Betaxolol and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol carefully with continuous hemodynamic monitoring, and have vasopressors and anticholinergics available. Continue chronic beta-blockers perioperatively unless otherwise indicated.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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