Drug interactions
Bethanechol + Clomipramine
Severity: Moderate
Bethanechol and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine has strong anticholinergic activity that can oppose the muscarinic effects of bethanechol. This may reduce bethanechol's benefit in urinary retention, which tricyclic antidepressants themselves can cause.
What this interaction means in plain words
Bethanechol and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bethanechol belongs to Gastrointestinal Tract; Clomipramine belongs to Central Nervous System.
Why it happens
Anticholinergic muscarinic blockade by clomipramine opposes bethanechol's agonist action.
What to do
Monitor urinary function and response to bethanechol; consider an antidepressant with lower anticholinergic activity if retention persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bethanechol
- Bethanechol + Darifenacin Major
- Bethanechol + Fesoterodine Major
- Bethanechol + Oxybutynin Major
- Bethanechol + Physostigmine Major
- Amifampridine + Bethanechol Moderate
- Amitriptyline + Bethanechol Moderate
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Bethanechol with Clomipramine?
MediHelp rates the interaction as moderate. Bethanechol and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine has strong anticholinergic activity that can oppose the muscarinic effects of bethanechol. This may reduce bethanechol's benefit in urinary retention, which tricyclic antidepressants themselves can cause.
How serious is the interaction between Bethanechol and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary function and response to bethanechol; consider an antidepressant with lower anticholinergic activity if retention persists.
What other medicines interact with Bethanechol?
MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Fesoterodine, Oxybutynin. The full list is on the Bethanechol page.
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