Drug interactions
Bethanechol + Dicyclomine
Severity: Moderate
Bethanechol and Dicyclomine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicyclomine is an antimuscarinic antispasmodic that opposes bethanechol's stimulation of gastrointestinal and bladder smooth muscle. Therapeutic effects of both drugs may be diminished.
What this interaction means in plain words
Bethanechol and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bethanechol belongs to Gastrointestinal Tract; Dicyclomine belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Avoid concurrent use where possible; if both are needed, monitor symptom control and urinary output.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bethanechol
- Bethanechol + Darifenacin Major
- Bethanechol + Fesoterodine Major
- Bethanechol + Oxybutynin Major
- Bethanechol + Physostigmine Major
- Amifampridine + Bethanechol Moderate
- Amitriptyline + Bethanechol Moderate
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Bethanechol with Dicyclomine?
MediHelp rates the interaction as moderate. Bethanechol and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicyclomine is an antimuscarinic antispasmodic that opposes bethanechol's stimulation of gastrointestinal and bladder smooth muscle. Therapeutic effects of both drugs may be diminished.
How serious is the interaction between Bethanechol and Dicyclomine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if both are needed, monitor symptom control and urinary output.
What other medicines interact with Bethanechol?
MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Fesoterodine, Oxybutynin. The full list is on the Bethanechol page.
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