Drug interactions
Betrixaban + Progesterone
Severity: Moderate
Betrixaban and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progesterone may inhibit P-glycoprotein and raise betrixaban exposure, which increases bleeding risk. Betrixaban labeling calls for a dose reduction with P-gp inhibitors.
What this interaction means in plain words
Betrixaban and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Progesterone inhibits P-glycoprotein-mediated efflux of betrixaban.
What to do
Monitor for bleeding and follow betrixaban labeled dose reduction if a P-gp inhibitor is considered clinically relevant. Consider alternative anticoagulant if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Frequently asked questions
Can I take Betrixaban with Progesterone?
MediHelp rates the interaction as moderate. Betrixaban and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Progesterone may inhibit P-glycoprotein and raise betrixaban exposure, which increases bleeding risk. Betrixaban labeling calls for a dose reduction with P-gp inhibitors.
How serious is the interaction between Betrixaban and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and follow betrixaban labeled dose reduction if a P-gp inhibitor is considered clinically relevant. Consider alternative anticoagulant if bleeding risk is high.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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