Drug interactions
Enzalutamide + Progesterone
Severity: Major
Enzalutamide and Progesterone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide, a strong CYP3A4 inducer, may substantially lower progesterone exposure. This may reduce efficacy, including endometrial protection or contraceptive effect.
What this interaction means in plain words
Enzalutamide and Progesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Progesterone belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, accelerating progesterone metabolism.
What to do
Avoid the combination where possible and use an alternative non-hormonal contraceptive when needed. If progesterone is essential, monitor for loss of effect and breakthrough bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Progesterone
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Progesterone?
MediHelp rates the interaction as major. Enzalutamide and Progesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide, a strong CYP3A4 inducer, may substantially lower progesterone exposure. This may reduce efficacy, including endometrial protection or contraceptive effect.
How serious is the interaction between Enzalutamide and Progesterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative non-hormonal contraceptive when needed. If progesterone is essential, monitor for loss of effect and breakthrough bleeding.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Mavacamten. The full list is on the Progesterone page.
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