Drug interactions
Mifepristone + Progesterone
Severity: Major
Mifepristone and Progesterone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is a progesterone receptor antagonist and so directly opposes progesterone action. It also inhibits CYP3A4, which may raise progesterone concentrations, but the receptor antagonism dominates clinically.
What this interaction means in plain words
Mifepristone and Progesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Progesterone belongs to Endocrine.
Why it happens
Competitive progesterone receptor antagonism by mifepristone, with additional CYP3A4 inhibition.
What to do
Do not use progesterone to support a pregnancy when mifepristone is given, as this is pharmacologically contradictory; separate use should follow the specific clinical protocol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Progesterone
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Progesterone?
MediHelp rates the interaction as major. Mifepristone and Progesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone is a progesterone receptor antagonist and so directly opposes progesterone action. It also inhibits CYP3A4, which may raise progesterone concentrations, but the receptor antagonism dominates clinically.
How serious is the interaction between Mifepristone and Progesterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use progesterone to support a pregnancy when mifepristone is given, as this is pharmacologically contradictory; separate use should follow the specific clinical protocol.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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