Drug interactions
Apalutamide + Progesterone
Severity: Major
Apalutamide and Progesterone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong inducer that may substantially reduce progesterone exposure. This may cause loss of endometrial protection in estrogen-treated women or failure of luteal support.
What this interaction means in plain words
Apalutamide and Progesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Progesterone belongs to Endocrine.
Why it happens
Apalutamide induces CYP3A4, increasing the metabolism of progesterone.
What to do
Avoid the combination where possible. If used, monitor for breakthrough bleeding or reduced effect and consider an alternative therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Progesterone
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Progesterone?
MediHelp rates the interaction as major. Apalutamide and Progesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong inducer that may substantially reduce progesterone exposure. This may cause loss of endometrial protection in estrogen-treated women or failure of luteal support.
How serious is the interaction between Apalutamide and Progesterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor for breakthrough bleeding or reduced effect and consider an alternative therapy.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Carbamazepine, Enzalutamide, Mavacamten. The full list is on the Progesterone page.
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